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6-Bromohexanoic acid


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CAS: 4224-70-8
MF: C6H11BrO2
MW: 195.05
EINECS: 224-176-5
Product Categories: C6;Carbonyl Compounds;omega-Functional Alkanols, Carboxylic Acids, Amines & Halides;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks;Organic acids;Acids & Esters;Bromine Compounds;omega-Bromocarboxylic Acids;Aliphatics;Miscellaneous Reagents;Building Blocks
Mol File: 4224-70-8.mol
Article illustration

6-Bromohexanoic acid Chemical Properties
Melting point 32-34 °C (lit.)
Boiling point 165-170 °C/20 mmHg (lit.)
density 1.3996 (rough estimate)
refractive index 1.4790 (estimate)
Fp 154 °F
storage temp. Inert atmosphere,2-8°C
solubility methanol: 0.1 g/mL, clear, colorless
pka 4.72±0.10(Predicted)
form Low Melting Crystals
color White to light orange
BRN 1749740
InChIKey NVRVNSHHLPQGCU-UHFFFAOYSA-N
LogP 1.700 (est)
CAS DataBase Reference 4224-70-8(CAS DataBase Reference)
NIST Chemistry Reference Hexanoic acid, 6-bromo-(4224-70-8)
EPA Substance Registry System Hexanoic acid, 6-bromo- (4224-70-8)
6-Bromohexanoic acid Usage And Synthesis
Organic Intermediate 6-bromohexanoic acid(CAS:4224-70-8), also called 6-bromohexanoic acid or 6-bromo-hexanoic acid, is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. 6-Bromohexanoic acid is used in the preparation of N-acylsulfonamides, diarylthioethers and 2-lithio-1,3-dithian. It is widely used as an intermediate in organic synthesis. Here, we introduced a method for making this compound.
Chemical Properties White to light orange low melting crystals
Uses Employed in a direct preparation of N-acylsulfonamides on treatment with tosyl isocyanate (189278)1 and alkyl ketones from alkyl iodides and metallic strontium.2
Uses 6-Bromohexanoic acid is used in the preparation of N-acylsulfonamides, diarylthioethers and 2-lithio-1,3-dithian. It is widely used as an intermediate in organic synthesis.
Uses 6-Bromohexanoic acid was used in the preparation of N-acylsulfonamides on treatment with tosyl isocyanate (189278) and alkyl ketones from alkyl iodides and metallic strontium. It was also used in the synthesis of anionic mitomycin C-dextran conjugate (MMC-D), 2-lithio-1,3-dithian and diaryl thioethers.
Definition ChEBI: 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It is functionally related to a hexanoic acid.
Synthesis Reference(s) Journal of the American Chemical Society, 72, p. 5137, 1950 DOI: 10.1021/ja01167a091
Synthesis The preparation method of the high purity 6-bromocaproic acid: the exsiccant bromize hydrogen gas is directly fed contain in the organic solvent of 6-caprolactone, exsiccant bromize hydrogen gas usage quantity is 6-caprolactone 1.0-2.0 doubly (mol ratio); Stir, ring-opening reaction takes place, temperature of reaction is 0 ℃ ~ 100 ℃, generates high purity 6-bromocaproic acid.
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Shanghai Ouda New New Material Science and Technology Center,located in Fengxian District, Shanghai. The company produces more than 1000 kinds of high-quality products I20 production lines to provide OEM services, as one of the most dynamic industry and trade integrated companies in the Chinese market.our advantage comes from our service, we can provide fast delivery. The average delivery time in peak season is less than 15 working days, and the average delivery time in off-season is less than 1 month. We have successfully transported many chemical raw materials to many countries in the world. Good feedback and repeat orders have supported the growth of our company.independent production lines, we have 20 pharmaceutical raw materials, organic solvents and other raw material production lines. In addition, we also have an API production workshop with independent research and development production lines, as well as an API research and development testing center. We can provide you with sample testing and accept small orders. Supply 99%+ quality chemical products. We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Ouda will be your strong, sincere and reliable partner in China.

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Last Update : Apr 24, 2024 4:11 AM
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