Cloperastine hydrochloride (Business Opportunities - Marketing & Sales)

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Item ID 16112800 in Category: Business Opportunities - Marketing & Sales

Cloperastine hydrochloride


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Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with an IC 50 value of 27 nM.Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.
Intheanesthetizedguineapigs,Cloperastineatatherapeuticdoseof1mg/kgprolongedtheQTintervalandmonophasicactionpotential(MAP)durationwithoutaffectingPRintervalorQRSwidth.CloperastinehydrochlorideshowsrelativelylowacutetoxicChemicalbookitywhenadministeredbytheintraperitonealrouteinratsandmice,andshowsminortoxicitybytheoralroutewhenadministeredasCloperastinefendizoate,theLD50inratsandmiceforthetwoadministrationroutesexceeds1000and2000mg/kg,respectively.

Brand: Soarwin
CAS:14984-68-0
EC Number:239-067-8
Molecular Formula: C20H25Cl2NO
Melting point:147.9°


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Last Update : Jul 16, 2025 1:13 AM
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Item  Owner  : Anna
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