Severe hypocalcemia in dialysis-dependent elderly linked to Denosumab. (Health & Beauty - Health Services)

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Severe hypocalcemia in dialysis-dependent elderly linked to Denosumab.


A recent study published in the Journal of the American Medical Association has found that denosumab, a drug used to treat osteoporosis, is linked to a higher risk of severe or very severe hypocalcemia in female patients aged 65 or older who are dependent on dialysis.

The research was led by Steven T. Bird, Ph.D., Pharm.D., from the U.S. Food and Drug Administration, and his team. They conducted a retrospective cohort study comparing the risk of severe hypocalcemia in patients treated with denosumab and those treated with oral bisphosphonates. Severe hypocalcemia was defined as total albumin-corrected serum calcium less than 7.5 mg/dL or a primary hospital or emergency department diagnosis of hypocalcemia. Very severe hypocalcemia was defined as serum calcium less than 6.5 mg/dL.

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Target State: New York
Target City : New York City
Last Update : Sep 01, 2025 2:24 AM
Number of Views: 28
Item  Owner  : medhealthinsight
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2025-09-14 (1.207 sec)